Blood clotting enzyme Essay Example for Free

Blood clotting enzyme Essay Serine protease proteins are important enzymes involved in the process of blood coagulation. Blood coagulation is an importance defense mechanism that prevents the host mammal organism from losing excess blood or from forming unwanted blood clot. The process of coagulation can be initiated by both intrinsic factors and extrinsic factors. A cascade of event is followed which activate these enzymes; normally the enzymes are inactive state a condition called zymogens. Zymogens by their virtual condition of being inactive prevent unwanted blood clotting which may have a far reaching consequence such as thrombosis. Blood clotting in a series of processes, in which the zymogens’ need to be activated by reacting with its glycoprotein co-factors. Among the serine protease is the thrombin enzyme factor five (v) responsible for clearing clot in the blood. The enzyme is usually present circulating in plasma which is made up of a single monomer chain, it life span can range from 12 to 36 hours. In human the main regulator in blood coagulation is erythrocytes leukemia cells which activate adenylate cyclase, the process is reversible by the interaction of Aalpa-thrombin with glycoprotein while b alpha enhance the platelets interaction which initiate the proteolytic process. Fibrin-bound thrombin is cleaved by thrombin at a very specific site at the extracellular N-terminal, PAR-1 regulates a number of endothelial cell biology, vascular development but more so is a mediator of thrombin signaling. The human thrombin consist of two gamma chains namely the gamma A and gamma’ the final stage of coagulation of mammalian blood involves the cleavage of the four arginine and glycine bond. Binding studies shows both fibrin 1 and fibrin 2 with low affinity to the E domain and high binding affinity at the extreme end of 408 to 425 on the gamma chain The mode of action involves conversion of fibrinogen to fibrin by breaking the bonds in the fibrinogen at a precise position of arginine and glycine where the fibrin peptides are released. The serine proteases require restructuring itself in order to fit the key and lock model. The glycine at the position five is highly conserved because it is the one which occupy the active site which is determine by the acryl group during the substrate conformation. Asparagines 189 help the enzyme to easily recognize the substrate. The active site is entirely made of histidine 57, asparagines 102, serine 195 and serine 214. The reaction on many a times prefers position 1 to position 4 during remodeling, therefore the type of protein presence to a large extend determine the kind protease and also the kind of cleavage to take place. Thrombin activation is regulated by pentapeptide of the COOH terminus of the factor (v) heavy chains. Thrombin and thrombin receptors is another regulatory point where they both posses strong protective barrier and at the same time cancerous cells were eliminated by apoptosis. A study carried out using mitochondrial membranes which were depolarized using attenuated Catalase lead to controlled cell death. Statistical finding indicate that 30% of the population carried world wide indicated that activated peptide segment at position 4 of factor eight caused a substitution in V34L after binding the structure and analyzing the interaction according to (Brenda 2010). The switching of receptor is PAR-1-dependent signaling specifically to thrombin resulting inhibition of adhesion cell surface which activate thrombin the ligand occupancy position switches the protease receptor by signaling specifically to the thrombin. Human cell in culture indicated low amount of thrombin and receptor PAR-1 agonist induced strong anti-inflammatory activities which was secondary effect of the low concentration of thrombin after activation by P13 kinase and PAR-1. Thrombin like other enzymes is very specific in the binding domain and the insertion loop which is determined by the residues involved in ligand binding as result of interaction glycoprotein and protease receptor on the platelet membrane. This uniqueness makes it very efficient in it task according to (Webert 2006). The enzyme play vital role in homeostasis, cell differentiation, thrombosis and activation of blood cell types, on exposure to phosphatidylserine on the outer surface the platelets were stimulated. A study done using heparin indicated an overlap of the active site, which was attributed to the interaction of thrombin and the gamma peptide chains to the external and the interaction to the active site in close proximity to the Na+ of the substrate. The role of the enzyme can be explained in terms of NA+ binding to thrombin on the basis of prothrombotic and procoagulant. The cascade is a continuous cycle of events that are activated by two factors ,factor (ix) and factor (viii) to form tenase complex which is discontinued by down regulation that occur in the following mechanism which include; serpin (serine protease inhibitors) which function to degrade thrombin and other activation factors, it can also be regulated by protein C where thromodulin bind to it and is inactivate in the presence of protein S, limiting the action of tissue factor by the tissue factor pathway inhibitors by inhibiting excessive TF mediated activation of factor (ix) and factor (x), plasmin help to degrade fibrin hence preventing more fibrin being formed and lastly but not the least regulation through adenylate cyclase pathway by inhibiting platelet activation by decreasing cytosol level of calcium which ultimately result to decreased release of granules which are responsible for the activation of more platelets and coagulation cascade. In conclusion the work play by thrombin enzyme is of paramount importance considering the complexity of the enzyme kinetics involved in the human body. References Brenda Enzyme database retrieved on 13 August 2010 from http://www. brenda-enzymes. org/php/result_flat. php4? ecno=3. 4. 21. 5 Furie B, Furie BC (2005). Thrombus formation in vivo. J. Clin. Invest. 115 (12): retrieved on 12 August 2010 from http://www. jci. org/cgi/content/full/115/12/3355. Webert KE, Cook RJ, Sigouin CS, (2006). The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia. haematologica .

The Iron Lady Movie Analysis

The Iron Lady Movie Analysis In this paper, the writer is going to analyze a character named Margareth Thatcher in The Iron Lady movie. The Iron Lady movie is a biopic film which tells the journey of Margaret Thatchers life. Margaret Thatcher is a woman politician who has strong influence in the world. She was successful in trace the history as the first woman Prime Minister in England whom occupied that position for more than one decade. This movie shows many fluctuations in politic, economy, and social field in the arrangement of the government and society which happened in that time. Thus, it can be said that movie, one example of popular culture, is actually a cultural product which represents the societys beliefs, values, and norms. (Nachbar Lause, 1992). Williams (2010) says that there are some examples of popular culture which give a huge effect and become popular in over the world such as fashion, television, music, and movie. It can affect both positively or negatively. The writer choose Margareth Thatcher as the object of the writers study because the writer wants to reveal that in the past time even in recent days women are oppressed in a political field, they have not been given chances to show their ability to lead the society. However, Margareth Thatcher shows her ability to carry out the Britains government. Margareth Thatcher was born on October 13, 1925, in Grantham, England. She is the daughter of a local businessman who was introduced to conservative politics by her father, a member of the towns council. When she was in university, she served as a president of the Conservative Association. Two years after she graduated from her college, she accepted to work for public office. She ran as the conservative candidate for a Dart ford parliamentary seat in the 1950 elections. She was elected to be a leader of the Conservative Party in 1975. She served as the prime minister of England from 1979 to 1990. As a prime minister, she battled the countrys recession by initially raising interest rates to control inflation. She can run the country quite well marked with some progression that has been occurred in that time. Moreover, she shows her valor when she accepted to be the first female Prime Minister in England by a lot of contradiction come from the government and the society. Besides, she i s an inspiring leader for the writer. She exemplifies how a woman leader in reality ought to behave. The writer will discuss this character using the perspectives of women stereotype, oppression, and movement in accordance to Marxist feminism theory. The theory separates men and womens power in social and economic field. It also talks about power inequality between men and women in a society. From the film, Margareth Thatcher shows her desire to have the same right, chance, and position in the society where in that time women were usually been oppressed by the men. Therefore, the writer chooses to use this theory. Having considered the above facts, therefore the writer proposes a study entitled Feminism Analysis in Phyllida Lloyd (2011) Iron Lady Movie: A Study of Women Stereotype, Oppression, and Movement. Field of the Study This study belongs to both Literature and Film Studies. Scope of the Study This study will put limitations on what is going to be analyzed as follows: The writer will analyze the feminism side of a character in The Iron Lady movie, Margareth Thatcher, using Marxist feminism theory. The writer will analyze the cinematographic visualization in the film which confirms women stereotype, oppression, and movement towards the character. Problem Formulation / Research Questions This research aims to answer the following question: What are women stereotype, oppression, and movement which are defined in the film? What are the perspectives of women stereotype, oppression, and movement according to Marxist feminism theory? How does the cinematographic visualization in the film confirm women stereotype, oppression, and movement from the perspective of Marxist feminism? Objectives of the Study This research is conducted to achieve this objective: To reveal the women stereotype, oppression, and movement in the film. To define the perspective of women stereotype, oppression, and movement according to Marxist feminism theory. To show the cinematographic visualization in the film which confirms women stereotype, oppression, and movement from the perspective of Marxist feminism. Significance of the Study The writer conducts this research to inform the readers about what was going on in the past time toward women in England who were been oppressed by the men. Moreover, the writer also wants to give her assumptions and criticism concerning to the gender stereotype which happens in the society nowadays. Definitions of Terms To prevent misunderstandings towards this study, the writer will give some definition of terms which are related to this study. Film: Film is another word that means different things in different contexts: roll film, stock, a film, to film. We were all exposed to some kind of film before we saw our first example of classic moviemaking. It may have been something we saw on television: a cartoon, a Three Stooges short, a Lassie rerun. Or perhaps it was an educational film we saw in school or a theatrical film (a film intended to be shown in movie theaters). (Anatomy of Film, Bernard Dick, 1978, pp.1-2) Marxist feminism: Marxist feminism is organized around the basic conflicts between capitalism versus patriarchy and class versus gender oppression. Marxist feminism combines the study of class with the analysis of gender. (Feminist Theory and Literary Practice, Deborah L. Madsen, 2000, p.65) Stereotype: Stereotype is fixed ideas about individuals, groups or objects. Stereotypic thinking about sex-role related personality features is pervasive. Desirable features assign men to form a competence cluster, while womens features form a warmth-expressive cluster. (Broverman, 1972, as cited in The Dictionary of Feminist Theory, Maggie Humm, 1995, pp.277-278) Oppression: The experience of oppressed people is that the living of ones life is confined and shaped by forces and barriers which are not accidental or occasional and hence avoidable, but are sys ­tematically related to each other in such a way as to catch one between and among them and restrict or penalize motion in any direction. (Oppression and the Use of Definition, Marilyn Frye, p.3) Political movement: The activities about someone during a particular period of time or a group of people who works together to advance their shared political ideas. (Oxford Dictionaries Online) Cinematographic visualization: The essential techniques, methods, and elements people use to tell the story. (Cinematography Theory and Practice: Image Making for Cinematographers and Director, Blain Brown, 2011, p.3) Review of Literature There are some theories that can support the writers research, they are: Feminism in European Politics The difference between struggling classes and the ruling classes in Marxist teaching has clearly led each class to do social struggle. However, when we are speaking about gender roles in such a stratified society, the class struggle is simply a cause to gender stereotypes and exploitation. (Madsen, 2000) Gender stereotypes is actually a set of values of being proper and improper to be done by a woman which is functioned as a limitation These values often create an unfriendly environment or even such condition for women to take part in legal and social functions. Furthermore, it supports a condition that womens rights are susceptible to violation. There are many kinds of stereotypes and several reasons of stereotypes. According to Cook Cusack (2010, pp.25-28), there are three kinds of stereotypes, they are sex stereotypes, sexual stereotypes, and sex role stereotypes. Sex stereotypes, are supposedly based on the physical or biological differences. Sexual stereotypes are those based on the perceived characteristics that play a role in sexuality, including, for example, sexual initiation, intimacy, possession, and objectification while sex role stereotypes describes a normative or statistical view regarding appropriate roles or behavior for men and women. Josephson (2005) in her book Gender and American Politics: Women, Men, and the Political Process: Tolleson-Rinehart explains the examples of discrimination among women and men government workers in western legal system. She says that among others, women usually suffer in terms of peoples trust, media coverage, and self-inconfidence from their male counterparts. Based on Gelbs theory of feminism and politics: a comparative perspective (1989), there are two kinds of feminist movement in power-seizing political fields, they are the reformists and radicals. Both of them move based on their own ideology of how women should be participating in such conditions. According to Jonasdottir (1994), oppression based on gender stratification is similar to Marxist class division where the gender woman has been named as the second gender. Thus it makes women are vulnerable to discriminate based on what Marxism defines as materialistic and economic value. The conceptual tools of cinematography Blain Brown (2011, p.3) in his book Cinematography Theory and Practice: Image Making for Cinematographers and Director says that the tools of cinematography and filmmaking actually discuss the essential techniques, methods, and elements that we can use to tell the story. Some elements in cinematography visualization which can be used to support this study are camera angles, shot sizes, and techniques of framing. According to Bernard Dick, a shot is simply what is recorded by a single operation of the camera. He also states that it can also be defined in terms of distance. (1998, pp.36-37). In other words, shot is a matter of subjects size or amount in the frame. It embodies five types; they are close up (CU), extreme close up (ECU), long shot (LS), extreme long shot (ELS), and medium shot (MS). He also says that shots are also defined by the position of the camera in relation to the subject or what do we known as angle. It is determined by where the camera is placed. There are four types of angle; they are birds eye view, high-angle (h/a), low-angle (l/a), and oblique-angle. In framing techniques, there is a rule called rule of thirds. Rule of thirds is a guideline which applies to the process of composing visual images such as paintings, photographs, and designs. It proposes that an image should be imagined as divided into nine equal parts by two equally-spaced horizontal lines and two equally-spaced vertical lines, and that important compositional elements should be placed along these lines or their intersections. When we are photographing or filming people, it is common to line the body up with a vertical line, and having the persons eyes in line with a horizontal one. (2012, Rule of Thirds,  ¶.1). Method of Data Collection Analysis Method of Data Collection The writer uses film as the instrument of this study, documentary research as the technique to conduct this research and qualitative approach to analyze the object. The writer chooses such technique and approach because the writer wants to analyze the object in depth. Method of Data Analysis Thus far, the writer has done watching the movie and collecting the data. The writer has used library and internet resource to assist completing this research.

The Ideology of Keynes Essay -- Keynes

The Ideology of Keynes There is a certain degree of irony in considering the iconic figure that Keynes has become. For a man who was so thoroughly iconoclastic, rejecting established ideologies always in favor of his own, that he has become nearly synonymous with a mode of government or at least a school of economic thought, seems to be the richest sort of irony. In his Essays in Pursuasion, Keynes wrote the short piece â€Å"Am I a Liberal?† that took on the established political system of the time and thoroughly rejected it. For those seeking a quick answer to questions about the politics of his enigmatic General Theory, â€Å"Am I a Liberal?† would seem to raise more questions than it answers. Nevertheless, Keynes makes it abundantly clear what he is not. He rejects the Conservatives and the Labour parties out of hand. While he seems to have contempt for the former, he cites the latter as a difference of class. The Labour party, for him, is one that is constructed around the notion of class conflict and class issues, which he cannot partake in from across the supposedly ...

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Julius Caesar How did the Emperor rise to power? Julius was born from Aurelia and Gaius Julius Caesar. His family had nobility status, although they were neither rich nor influential in the time period. Caesar was made military tribune before 70 B.C. and was quaestor in Farther Spain in 69 B.C. he helped Pompey to obtain the supreme command for the war in the East. As a general, Caesar was the best Rome had ever seen. He returned to Rome in 68 B.C. and in Pompey's absence was becoming the recognized head of the popular party. His love of Marius and Cinna made him popular with the people, but earned him the hatred of the senate. In Dec. 63 B.C. Caesar advocated mercy for Catiline and the conspirators, thereby increasing the enmity of the senatorial party and its leaders, Cato the Younger and Quintus Lutatius Catulus. How did they change the Empire of Rome? Julius Caesar was Rome’s first dictator, although he did not ever officially become Emperor. Caesar was appointed a counsol, and went...

A Most Remarkable Teacher Essay -- Medicine College Admissions Essays

A Most Remarkable Teacher    A most remarkable high school teacher first aroused my interest in medicine when he invited me to take a special advanced microbiology course at night. He (Mr. Wiles) had worked for years in the medical field before retiring to teach school. Spending many hours with us, he constantly reaffirmed his belief that we could make a positive contribution to society through a career in medicine. Shortly after my graduation, Mr. Wiles died of lung cancer. During his last months, as I visited him, walked with him, chopped wood for him, I anguished over my helplessness as his pain grew and his life diminished. The doctors couldn't do much to reverse that process, but at least they could t~ to ease his pain or Blow the spreading disease. I admired and envied that ability.    In the ensuing years, I found myself embracing two seemingly different career paths. I loved being around people and thrived on the interaction, but I was fascinated by the technical intricacies of science. With a love for my science courses, I found that I could readily follow the logic of scientific thought. Then I left school and went to Europe as a volunteer missionary. In addition to learning a foreign Language (French) †¢ I spent that year and a half learning to work with people and help them with their problems. This strengthened my desire to work with people in some kind of clinical setting.    It was... ...e good, some not as good--as they made their rounds. The really good ones seemed able to comfort their patients in more than just a physical sense. One oncologist seemed never to fail to bring a smile to his patients' faces, such was his genuine caring.    I believe, now, the words of Mr. Wiles. I believe that as a physician I can make a very real contribution to society. I can see myself offering all I have to help a patient smile again, using all my resources to find the best scientific solution. And as I become more of a scientist, so must I become even more skilled with people--people with needs and feelings. For medicine is the culmination of that art and science-requiring the best of both worlds.

Management and Planning

Tyco Company is a multinational group of companies that are destined to providing manufacturing services based on telecommunications as well as electronics.   It also provides services on security and healthcare.   The corporation of Tyco Electronics has experienced quite a rapid growth for the past few years, and it is today ranked as the world’s largest manufacturer of components. Management planning is a broad concept that ideally entails definition of the process of engaging all the resources and stakeholders of a particular business enterprise in order to accomplish the set goals of the business, which include success and long-term prosperity.   Planning is very crucial to management because having a plan on how all the business resources are managed is the first step to success of the business. Tyco Company has exercised a very high degree of planning for its management.   Planning has enabled the company to wisely and economically manage its process assets.   These assets include the stipulated standards as well as policies that govern the Tyco Company.   These process assets that have been well managed through proper planning within the Tyco Company are risk categories, whereby risk management planning has been emphasized roles as well as responsibilities of each member of the company that is the workforce, the management team and the stakeholders, and finally processes of decision making within the company. Tyco Company has also been able to plan for managing the company’s environmental factors.   These factors disclose tolerance that whole company organization and the stakeholders’ experience.   Understanding of these factors have enabled the whole Tyco Company organization and the stakeholders to be satisfied with decisions that reward the level as well as the density of risk management that is applied in the company.   Budgeting is also very important in any organization.   Therefore planning on how to manage budgeting has been a key issue in Tyco Company and this has contributed to even distribution of resources within the different branches of the company organizations.   Planning has also ensured that such overlooked issues in many companies such as risk management are considered and budgeted for. Time is always a constraint and time management is a very important aspect that should be stressed on by every organization that seeks to succeed.   Tyco Company has a well plan for time management, something that has ensured coherence among the various companies’ departments (Drucker,Harper & Row,1954).Planning for time management has also helped Tyco Company in fast manufacture, and supply of its products such electronics in time and as well, time service provision. This has highly boosted the company’s credibility and reliability, while at the same time rising to the higher levels of success. There are legal issues that arise within the Tyco Company. The fact that Tyco Company is a multinational Company means that it has several business operations in different states of countries. Each country is bound to have a different scale for tax payment.  Ã‚   In some countries, therefore, Tyco Company meets a lot of expenses through tax payment and this affects planning for budgeting management.   Planning is hence affected on the basis of budgeting due to this legal issue. Ethics deals with good relations towards others or the moral standards that are expected in the society.   Tyco Company has been able to maintain high ethical practices by understanding that, ethics as far as a business is concerned, begins right from the top.   The top managers in the Tyco Company therefore have been able to observe high critical standards hence setting a good example for the employees at the lower level to emulate.   This has enhanced management planning through establishment of a strong relationship and trust among the company’s staff, and the entire society. Drucker, Harper & Row, 1954). The company also exercised quite high social responsibility standards. It identifies and work s towards mentioning its customers through establishing good employee customer relations.   This has affected the management planning for Tyco Company since the company’s reliability is heightened and the customers are assures for the companies time management. Tyco Company has also laid down strategic contingency, operational as well as tactical plans.   Strategic planning is a process though which a company’s goal that are long term are determined at also involves identification of the most appropriate approach though which these goals can be achieved. Contingency planning involves putting into place long-term measures that are aimed at responding to any unlikely disaster that is bound to occur.   It involves planning for the unexpected. Operational planning involves all the activities that are short term and are geared to operating together towards success of the company while tactical planning involves planning for immediate future. All these plans are influence by various factors in any company.   In Tyco Company, lack of adequate resources such as funds and time has entirely affected perfect strategic, contingence, operational and tactical planning.   Most of the funds and available time is committed to expanding the business networks and technology as well as providing in service training to the companies workforce. (Thompson & Sheldon, 2003). Lack of qualified personnel who can deliver reliable plans has been another factor that has influenced the company’s strategic, tactical, operational and contingency planning.   This has led to increased chances of for instance, future risks since there are no firm laid grounds for risk management plans.   Unqualified personnel have also led to a problem of not documenting all the research and activities that the plans establish. This planning is also influenced by credibility which is created by representative participation, clear documentation as well as adhering to the rules of achieving the complete process. References. Drucker P. F. Harper & Row. (1954).The Practice of Management.

Causes of Air Accidents

Air Accident An Air accident is the worst nightmare of every pilot or passenger that has ever ridden in an aircraft. Although air travel is one of the safest forms of transportations, accidents do happen with dramatic and terrifying results. The circumstance of Air accidents takes place by four causes: takeoff and landing, mechanical failures, pilot error, and bad weather. One cause of Air accidents take place is during takeoff and landing. Approximately 80 percent of all aviation accidents occur shortly before, after, or during takeoff or landing, and are often described as resulting from â€Å"human error. The causes of Air accident is vary greatly depending on problems that may develop during the flight possess. In many situations these accidents can be completely avoided through careful preparation and effective safety techniques. Taxi and Takeoff is one of the most important parts of a flight. The preflight and planning stages of the operation must be carefully done to prevent accidents and save many lives. Landing Accidents during Descent account for 36 percent of all general Air mishaps and are the most common type of accident.When combined, taxi and takeoff accidents account for about 22percent jet airplane accidents, and about 22percent of all fatalities. Another cause of Air accidents is mechanical failures. No form of transportation is completely safe, and no machine is completely foolproof. Mechanical failure is responsible for 13percent of all commercial airplane accidents. An airplane can crash if engine failure can come in form of simple stalling. It could be as worse as a complete detachment of the motor itself.Many Modern planes have more than one engine and this allows the plane to continue to fly when one is shut down. However, these other cases where all shut at one, or one after the other, and accident occur. Anything that can go wrong will go wrong. Tragically, this sometimes applies to Air accidents when mechanical failures occur. A some what different cause for Air accidents is a pilot error. When most people make mistakes at their jobs, their employment can be terminated.In contrast, when pilots are negligent or make errors while on their jobs, there is potential for hundreds of lives to be terminated. The pilots receive extensive training designed to prepare them to handle a wide variety of situations, but there are times when fatal mistakes are made. When flight crew and pilots do their jobs correctly, Air accidents are much less likely to occur. Another important cause of Air accidents is bad weather. For example, flying at peak thunderstorm times should be avoided.In addition, flying at night is no safer than flying in the day. The weather caused 4percent of Air accidents. However, other problems made up the remaining 4percent. Most plane crashes happen in the months of September and December. However, no one from any investigation knows almost Air accidents happened in these two months. In conclusion, the cir cumstance of Air accidents takes place by four causes: takeoff and landing, mechanical failures, pilot errors, and bad weather. Yet many airplane accidents still have unknown causes.